Build guides for Vayne on MOBAFire. Learn what runes and items make the best Vayne build in League of Legends (LoL).

Nov 18, 2025 · Find the best meta build guides for Vayne in 2025, Season 3 Patch 25.24. The MOBAFire community offers quality Vayne builds and knowledge to improve your performance …

Vayne has a very versatile kit, especially for a marksman: Mobility, hard CC, Invisibility, and True Damage! That's a dangerous combination on any champion, let alone a marksman, which is …

Oct 24, 2025 · Twitch is an even matchup against Vayne, where the key is to play safely, especially in the early levels. He doesn't have many direct threats, but his attack speed boost …

[25.23] VAYNE "ALL SHALL TREMBLE" SEASON 15 BUILD (2025). Vayne build guides on MOBAFire. League of Legends Premiere Vayne Strategy Builds and Tools.

Jun 12, 2024 · Hey there my name is Dread and this is my Lethality/AD Vayne guide for all the new players out there that are wanting to have fun in a bursting way!, I have been playing …

Nov 25, 2023 · Welcome to my comprehensive Vayne guide for high-elo play in Patch 13.18. I'm Trixiefix, an experienced ADC main, and in this guide, I will teach you everything you need to …

Nov 25, 2025 · An Orbwalker's Guide to Vayne. Vayne build guides on MOBAFire. League of Legends Premiere Vayne Strategy Builds and Tools.

This Vayne build is made with kindness and love for all of the Vayne players out there! I was really worried that nobody will make a Vayne build, so I'm here to help those people, who want to …

May 20, 2025 · This guide will take you step by step through everything you need to climb ranked with Vayne in Patch 25.10. We'll cover builds, ability orders, combos, threats, synergies, and …